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Table of Contents: Overview (J. Todd Weber) Chapter 1 - Importance and Implications of Appropriate Use of Antimicrobials/Principles 1. Epidemiology of resistant pathogens 2. Implications for morbidity and mortality 3. Issues in measurement and surveillance 4. Challenges to infection control 5. Impact of antimicrobial use on developing resistance 6. Importance of vectors beyond physician prescription (OTC antibiotics, antibacterial soaps and other household products, and animal feed). Significant Pathogens (Laurel Prehien - to be confirmed) Chapter 2 - Gram-positive bacteria 1. Streptococcus pneumoniae 2. Enterococci 3. Staphylococcus aureus 4. Other gram-positive bacteria Chapter 3 - Gram-negative bacteria 1. Enteric gram - negatives 2. Salmonella 3. Gonococcus/meningococcus 4. Other gram-positive bacteria (Martin Evans) Chapter 4 - Tuberculosis (Preston Church) Chapter 5 - Viruses 1. Herpesviruses 2. SARS 3. Childhood viral diseases 4. Other viral diseases (Claire Pomeroy, Christian Sandrock ) Chapter 6- Influenza 1. Influenza 2. Avian Influenza (Javed Siddiqui) Chapter 7 - Fungi 1. Candida 2. Other fungi (TBN) Chapter 8 - Parasites 1. Malaria 2. Trichomonas 3. Giardia Evidence-Based Management of Infectious Diseases (Arch Mainous, Bill Hueston) Chapter 9 - Upper Respiratory Conditions 1. Adult URI, sinusitis, acute bronchitis, pharyngitis, chronic bronchitis 2. Children URI, otitis media, pharyngitis, purulent rhinitis (Hier Nguyen) Chapter 10 - Pneumonia 1. Community acquired 2.Nosocomial (Jim Johnson - to be confirmed) Chapter 11- UTI (Alice Thornton) Chapter 12. STDs 1. GC 2.syphilis 3. Chlamydia 4. Others (Laura Hass) Chapter 13 - Gastrointestinal conditions 1. Peptic ulcer 2. Diarrhea 3. Hepatitis (TBN) Chapter 14 - Endocarditis (Avi Nath- to be confirmed) Chapter 15 - CNS infections 1. Meningitis 2. Encephalitis 3. Abscess 4. Prion diseases (Cassandra Salgado) Chapter 16 - Skin and Bone Infections 1. Skin and soft tissue - inc. necrotizing fasciitis 2. Bone and joint infections (Frank Romanelli) Chapter 17 - HIV Special Considerations (Paul Little and Arch Mainous) Chapter 18 - Strategies for Optimal Antimicrobial Use 1. Practice guidelines 2. Diagnostic tests and cost-effectiveness 3. Profiling and feedback of practices 4. Immunizations (TBN) Chapter 19 - Antimicrobial flora in the hospital (Vicki Morrison - to be confirmed) Chapter 20 - Immunocompromised patients - transplant, post-surgical, spinal cord, burns, elderly (Claire Pomeroy and Arch Mainous) Chapter 21- Future trends.